Publications
Kouzarides Lab Publications:
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Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorgia G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster N, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou G, Rausch O, Tzelepis K, Kouzarides T (2021)
Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Nature (2021). https://doi.org/10.1038/s41586-021-03536-w
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T (2017)
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Nature 552(7683):126-131.
Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, Stanley K, Sinha D, Yeh P, Morison J, Giotopoulos G, Lugo D, Jeffrey P, Lee SC, Carpenter C, Gregory R, Ramsay RG, Lane SW, Abdel-Wahab O, Kouzarides T, Johnstone RW, Dawson SJ, Huntly BJ, Prinjha RK, Papenfuss AT, Dawson MA (2015)
BET inhibitor resistance emerges from leukaemia stem cells.
Nature 525(7570):538-542
Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T. (2014)
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Nature. 507(7490), 104-108.
Tessarz P, Santos-Rosa H, Robson SC, Sylvestersen KB, Nelson CJ, Nielsen ML, Kouzarides T. (2014)
Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.
Nature.505(7484), 564-568.
Dawson MA, Prinjha RK, Dittman A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T. (2011)
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Nature. 478(7370), 529-533.
Dawson MA, Bannister AJ, Göttgens B, Foster SD, Bartke T, Green AR, Kouzarides T. (2009)
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Nature. 461(7265), 819-822.
Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, Bahler J, Green RD, Kouzarides T. (2007)
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.
Nature. 449(7164), 928-932. Additional data.
Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M. (2007)
Histone arginine methylation regulates pluripotency in the early mouse embryo.
Nature. 445(7124), 214-218.
Bannister AJ, Kouzarides T. (2005)
Reversing histone methylation.
Nature. 436(7054), 1103-1106.
Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T. (2002)
Active genes are tri-methylated at K4 of histone H3.
Nature. 419(6905), 407-411.
Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV, Laue ED. (2002)
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
Nature. 416(6876), 103-107.
Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O’Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE, Kouzarides T. (2001)
Rb targets histone H3 methylation and HP1 to promoters.
Nature. 412(6846), 561-565.
Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. (2001)
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Nature. 410(6824), 120-124.
Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. (1998)
Retinoblastoma protein recruits histone deacetylase to repress transcription.
Nature. 391(6667), 597-601.
Morkel M, Wenkel J, Bannister AJ, Kouzarides T, Hagemeier C. (1997)
An E2F-like repressor of transcription.
Nature. 390(6660), 567-568.
Milner J, Ponder B, Hughes-Davies L, Seltmann M, Kouzarides T. (1997)
Transcriptional activation functions in BRCA2.
Nature. 386(6627), 772-773.
Bannister AJ, Kouzarides T. (1996)
The CBP co-activator is a histone acetyltransferase.
Nature. 384(6610), 641-643.
White RJ, Trouche D, Martin K, Jackson SP, Kouzarides T. (1996)
Repression of RNA polymerase III transcription by the retinoblastoma protein.
Nature. 382(6586), 88-90.
Martin K, Trouche D, Hagemeier C, Sorensen TS, La Thangue NB, Kouzarides T. (1995)
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein.
Nature. 375(6533), 691-694.
Leger, A., Amaral P., Pandolfini, L., Capitanchik C., Capraro, F., Miano V,, Migliori, V., Toolan-Kerr, P., Sideri, t., Enright, AJ., Tzelepis, K., van Werven, FJ., Luscombe, NM, Barbieri, I., Ule, J., Fitzgerald, T., Birney, E., Leonardi, T & Kouzarides T.
RNA modifications detection by comparative Nanopore direct RNA sequencing.
Nat Commun 12, 7198 (2021).
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS. (2019)
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nat Commun. 9(1):5378.
Wein S, Andrews B, Sachsenberg T, Santos-Rosa H, Kohlbacher O, Kouzarides T, Garcia BA, Weisser H. (2019)
A computational platform for high-throughput analysis of RNA sequences and modifications by mass spectrometry
Nat Commun. 11(1):926.
Barbieri I and Kouzarides T (2020)
Role of RNA modifications in cancer.
Nature Reviews Cancer. 20, 303–322.
Tessarz P, Kouzarides T (2014) Histone core modifications regulating nucleosome structure and dynamics.
Nat Rev Mol Cell Biol 15(11):703-708
Gilan O, Lam EYN, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng C-F, Chan Y-C, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJP, Johnstone RW, Drewes G, Dawson S-J, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MA (2016).
Functional interdependence of BRD4 and DOT1L in MLL leukemia.
Nat Struct Mol Biol 23(7):673-681
Xhemalce B, Robson SC, Kouzarides T. (2012)
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing.
Cell. 151(2), 278-288.
Dawson MA, Kouzarides T. (2012)
Cancer epigenetics: from mechanism to therapy.
Cell. 150(1), 12-27.
Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T. (2010)
Nucleosome-interacting proteins regulated by DNA and histone methylation.
Cell. 143(3), 470-484.
Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. (2007)
New nomenclature for chromatin-modifying enzymes.
Cell. 131(4), 633-636.
Kouzarides T. (2007)
Chromatin modifications and their function.
Cell. 128(4), 693-705.
Nelson CJ, Santos-Rosa H, Kouzarides T. (2006)
Proline isomerization of histone h3 regulates lysine methylation and gene expression.
Cell. 126(5), 905-916.
Sanders SL, Portoso M, Mata J, Bahler J, Allshire RC, Kouzarides T. (2004)
Methylation of histone h4 lysine 20 controls recruitment of crb2 to sites of DNA damage.
Cell. 119(5), 603-614.
Cuthbert GL, Daujat S, Snowden AW, Erdjument-Bromage H, Hagiwara T, Yamada M, Schneider R, Gregory PD, Tempst P, Bannister AJ, Kouzarides T.(2004)
Histone deimination antagonizes arginine methylation.
Cell. 118(5), 545-553.
Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. (2003)
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Cell. 115(5), 523-535.
Bannister AJ, Schneider R, Kouzarides T. (2002)
Histone methylation: dynamic or static?
Cell. 109(7), 801-806.
Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD. (1996)
The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.
Cell. 87(7), 1261-1270.
Cell Rep. 2(3), 470-477.
Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, Faretta M, Fuks F, Lo Coco F, Kouzarides T, Nervi C, Minucci S, Pelicci PG. (2002)
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
Science. 295(5557), 1079-1082.
Bannister AJ, Kouzarides T. (2011)
Regulation of chromatin by histone modifications.
Cell Res. 21(3), 381-395.
Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Göttgens B, Kouzarides T. (2012)
Three Distinct Patterns of Histone H3Y41 Phosphorylation Mark Active Genes.
Cell Rep. 2012 Sep 27;2(3):470-7
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.
Mol Cell. 5:S1097-2765(21)00326-9. doi: 10.1016/j.molcel.2021.04.021.
Barbieri I and Kouzarides T (2020)
Role of RNA modifications in cancer.
Nature Reviews Cancer. 20, 303–322.
Pandolfini L, Barbieri I, Bannister A.J, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson S.C, Migliori V, Alendar A, ’Onofrio M, Balasubramanian S, Kouzarides T. (2019)
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation
Mol Cell Bio 74 (6) 1278-1290
Viré E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Aparicio S, Esteller M, Caldas C, Kouzarides T. (2014)
The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31.
Mol Cell. 53(5), 806-818.
Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, Schreiber SL, Mellor J, Kouzarides T. (2003)
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
Mol Cell. 12(5), 1325-1332.
Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Green RD, Kouzarides T. (2009)
Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2.
Nat Struct Mol Biol. 16(4), 449-451.
Santos-Rosa H, Kirmizis A, Nelson C, Bartke T, Saksouk N, Cote J, Kouzarides T. (2009)
Histone H3 tail clipping regulates gene expression.
Nat Struct Mol Biol. 16(1), 17-22.
Griffiths DS, Li J, Dawson MA, Trotter MW, Cheng YH, Smith AM, Mansfield W, Liu P, Kouzarides T, Nichols J, Bannister AJ, Green AR, Göttgens B.(2011)
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.
Nat Cell Biol. 13(1), 13-21.
Ancelin K, Lange UC, Hajkova P, Schneider R, Bannister AJ, Kouzarides T, Surani MA. (2006)
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.
Nat Cell Biol. 8(6), 623-630.
Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T. (2004)
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes.
Nat Cell Biol. 6(1), 73-77.
Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin SF, Daigo Y, Russell P, Wilson A, Sowter HM, Delhanty JD, Ponder BA, Kouzarides T, Caldas C. (2000)
Mutations truncating the EP300 acetylase in human cancers.
Nat Genet. 24(3), 300-303.
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T. (2000)
DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
Nat Genet. 24(1), 88-91.
Daujat S, Bauer UM, Shah V, Turner B, Berger S, Kouzarides T. (2002)
Crosstalk between CARM1 methylation and CBP acetylation on histone H3.
Curr Biol. 12(24), 2090-2097.
Partridge JF, Scott KS, Bannister AJ, Kouzarides T, Allshire RC. (2002)
cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site.
Curr Biol. 12(19), 1652-1660.
Bannister AJ, Miska EA, Gorlich D, Kouzarides T. (2000)
Acetylation of importin-alpha nuclear import factors by CBP/p300.
Curr Biol. 10(8), 467-470.
Brenner C, Deplus R, Didelot C, Loriot A, Vire E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L, Fuks F. (2005)
Myc represses transcription through recruitment of DNA methyltransferase corepressor.
EMBO J. 24(2), 336-346.
Kirsh O, Seeler JS, Pichler A, Gast A, Muller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A. (2002)
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
EMBO J. 21(11), 2682-2691.
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T. (2002)
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
EMBO J. 21(10), 2383-2396.
Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T. (2001)
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.
EMBO J. 20(10), 2536-2544.
Kouzarides T. (2000)
Acetylation: a regulatory modification to rival phosphorylation?
EMBO J. 19(6), 1176-1179. Review.
Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. (2000)
Regulation of E2F1 activity by acetylation.
EMBO J. 19(4), 662-671.
Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T. (1999)
HDAC4 deacetylase associates with and represses the MEF2 transcription factor.
EMBO J. 18(18), 5099-5107.
Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, Spohr G, Kouzarides T, Mohun TJ. (1999)
MEF-2 function is modified by a novel co-repressor, MITR.
EMBO J. 18(18), 5085-5098.
Vandel L, Kouzarides T. (1999)
Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
EMBO J. 18(15), 4280-4291.
Brehm A, Nielsen SJ, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. (1999)
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth.
EMBO J. 18(9), 2449-2458.
Reid JL, Bannister AJ, Zegerman P, Martinez-Balbas MA, Kouzarides T. (1998)
E1A directly binds and regulates the P/CAF acetyltransferase.
EMBO J. 17(15), 4469-4477.
Martinez-Balbas MA, Bannister AJ, Martin K, Haus-Seuffert P, Meisterernst M, Kouzarides T. (1998)
The acetyltransferase activity of CBP stimulates transcription.
EMBO J. 17(10), 2886-2893.
Larminie CG, Cairns CA, Mital R, Martin K, Kouzarides T, Jackson SP, White RJ. (1997)
Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein.
EMBO J. 16(8), 2061-2071.
Bannister AJ, Kouzarides T. (1995)
CBP-induced stimulation of c-Fos activity is abrogated by E1A.
EMBO J. 14(19), 4758-4762.
Brown HJ, Sutherland JA, Cook A, Bannister AJ, Kouzarides T. (1995)
An inhibitor domain in c-Fos regulates activation domains containing the HOB1 motif.
EMBO J. 14(1), 124-131.
Metz R, Kouzarides T, Bravo R. (1994)
A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth.
EMBO J. 13(16), 3832-3842.
Hagemeier C, Caswell R, Hayhurst G, Sinclair J, Kouzarides T. (1994)
Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.
EMBO J. 13(12), 2897-2903.
Frampton J, Kouzarides T, Doderlein G, Graf T, Weston K. (1993)
Influence of the v-Myb transactivation domain on the oncoprotein’s transformation specificity.
EMBO J. 12(4), 1333-1341.
Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS. (2005)
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
EMBO Rep. 6(7), 675-680.
Bauer UM, Daujat S, Nielsen SJ, Nightingale K, Kouzarides T. (2002)
Methylation at arginine 17 of histone H3 is linked to gene activation.
EMBO Rep. 3(1), 39-44.
Takei Y, Swietlik M, Tanoue A, Tsujimoto G, Kouzarides T, Laskey R. (2001)
MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.
EMBO Rep. 2(2), 119-123.
Burgess, HM., Depledge, DP., Thompson, L., Srinivas, KP., Grande, RC., Vink, EI., Abebe, JS., Blackaby, WP., Hendrick, A., Albertella, MR., Kouzarides, T., Stapleford, KA., Wilson, AC. and Mohr, I. (2021)
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes Dev, v. 35
Genes Dev. 35: 1005-1019.
Xhemalce B, Kouzarides T. (2010)
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.
Genes Dev. 24(7), 647-652.
Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. (2009)
An operational definition of epigenetics.
Genes Dev. 23(7), 781-783.
Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. (2000)
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
Genes Dev. 14(1), 45-54.
Hsieh JK, Fredersdorf S, Kouzarides T, Martin K, Lu X. (1997)
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
Genes Dev. 11(14), 1840-1852.
Sutherland JA, Cook A, Bannister AJ, Kouzarides T. (1992)
Conserved motifs in Fos and Jun define a new class of activation domain.
Genes Dev. 6(9), 1810-1819.
Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T. (2009)
Phosphorylation of histone H3 Thr45 is linked to apoptosis.
J Biol Chem. 284(24), 16575-16583.
Smith AE, Hurd PJ, Bannister AJ, Kouzarides T, Ford KG. (2008)
Heritable Gene Repression through the Action of a Directed DNA Methyltransferase at a Chromosomal Locus.
J Biol Chem. 283(15), 9878-9885.
Xhemalce B, Miller KM, Driscoll R, Masumoto H, Jackson SP, Kouzarides T, Verreault A, Arcangioli B. (2007)
Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe.
J Biol Chem. 282(20), 15040-15047.
Sims RJ 3rd, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D. (2005)
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.
J Biol Chem. 280(51), 41789-41792.
Bannister AJ, Schneider R, Myers FA, Thorne AW, Crane-Robinson C, Kouzarides T. (2005)
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes.
J Biol Chem. 280(18), 17732-17736.
Santos-Rosa H, Bannister AJ, Dehe PM, Geli V, Kouzarides T. (2004)
Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin.
J Biol Chem. 279(46), 47506-47512.
Schneider R, Bannister AJ, Weise C, Kouzarides T. (2004)
Direct binding of INHAT to H3 tails disrupted by modifications.
J Biol Chem. 279(23), 23859-23862.
Fuks F, Hurd PJ, Wolf D, Nan X, Bird AP, Kouzarides T. (2003)
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation.
J Biol Chem. 278(6), 4035-4040.
Wolf D, Rodova M, Miska EA, Calvet JP, Kouzarides T. (2002)
Acetylation of beta-catenin by CREB-binding protein (CBP).
J Biol Chem. 277(28), 25562-25567.
Zegerman P, Canas B, Pappin D, Kouzarides T. (2002)
Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex.
J Biol Chem. 277(14), 11621-11624.
Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T. (2000)
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
J Biol Chem. 275(13), 9461-9467.
Santos-Rosa H, Valls E, Kouzarides T, Martinez-Balbas M. (2003)
Mechanisms of P/CAF auto-acetylation.
Nucleic Acids Res. 31(15), 4285-4292.
Fuks F, Hurd PJ, Deplus R, Kouzarides T. (2003)
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase.
Nucleic Acids Res. 31(9), 2305-2312.
Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F. (2002)
Dnmt3L is a transcriptional repressor that recruits histone deacetylase.
Nucleic Acids Res. 30(17), 3831-3838.
Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T. (2001)
Differential localization of HDAC4 orchestrates muscle differentiation.
Nucleic Acids Res. 29(16), 3439-3447.
Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R, Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V, Renkawitz R. (2000)
Transcriptional repression by the insulator protein CTCF involves histone deacetylases.
Nucleic Acids Res. 28(8), 1707-1713.
Trouche D, Cook A, Kouzarides T. (1996)
The CBP co-activator stimulates E2F1/DP1 activity.
Nucleic Acids Res. 24(21), 4139-4145.
Bannister AJ, Brown HJ, Sutherland JA, Kouzarides T. (1994)
Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity.
Nucleic Acids Res. 22(24), 5173-5176.
Gibson TJ, Thompson JD, Blocker A, Kouzarides T. (1994)
Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.
Nucleic Acids Res. 22(6), 946-952.
Hagemeier C, Cook A, Kouzarides T. (1993)
The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro.
Nucleic Acids Res. 21(22), 4998-5004.
Bannister AJ, Gottlieb TM, Kouzarides T, Jackson SP. (1993)
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
Nucleic Acids Res. 21(5), 1289-1295.
Bannister AJ, Kouzarides T. (1992)
Basic peptides enhance protein/DNA interaction in vitro.
Nucleic Acids Res. 20(13), 3523.
Barlev NA, Emelyanov AV, Castagnino P, Zegerman P, Bannister AJ, Sepulveda MA, Robert F, Tora L, Kouzarides T, Birshtein BK, Berger SL. (2003)
A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription.
Mol Cell Biol. 23(19), 6944-69457.
Yang SH, Vickers E, Brehm A, Kouzarides T, Sharrocks AD. (2001)
Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
Mol Cell Biol. 21(8), 2802-2814.
Metz R, Bannister AJ, Sutherland JA, Hagemeier C, O’Rourke EC, Cook A, Bravo R, Kouzarides T. (1994)
c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein.
Mol Cell Biol. 14(9), 6021-6029.
Bernstein BE, Humphrey EL, Erlich RL, Schneider R, Bouman P, Liu JS, Kouzarides T, Schreiber SL. (2002)
Methylation of histone H3 Lys 4 in coding regions of active genes.
Proc Natl Acad Sci U S A. 99(13), 8695-86700.
Trouche D, Le Chalony C, Muchardt C, Yaniv M, Kouzarides T. (1997)
RB and hbrm cooperate to repress the activation functions of E2F1.
Proc Natl Acad Sci U S A. 94(21), 11268-11273.
Trouche D, Kouzarides T. (1996)
E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.
Proc Natl Acad Sci U S A. 93(4), 1439-1442.
Hagemeier C, Bannister AJ, Cook A, Kouzarides T. (1993)
The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.
Proc Natl Acad Sci U S A. 90(4), 1580-1584.
Burgers WA, Blanchon L, Pradhan S, Launoit YD, Kouzarides T, Fuks F. (2007)
Viral oncoproteins target the DNA methyltransferases.
Oncogene. 26(11), 1650-1655.
Iyer NG, Xian J, Chin SF, Bannister AJ, Daigo Y, Aparicio S, Kouzarides T, Caldas C. (2007)
p300 is required for orderly G1/S transition in human cancer cells.
Oncogene. 26(1), 21-29.
Milner J, Fuks F, Hughes-Davies L, Kouzarides T. (2000)
The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase.
Oncogene. 19(38), 4441-4445.
Zegerman P, Bannister AJ, Kouzarides T. (2000)
The putative tumour suppressor Fus-2 is an N-acetyltransferase.
Oncogene. 19(1), 161-163.
Fuks F, Milner J, Kouzarides T. (1998)
BRCA2 associates with acetyltransferase activity when bound to P/CAF.
Oncogene. 17(19), 2531-2534.
Vallian S, Gaken JA, Gingold EB, Kouzarides T, Chang KS, Farzaneh F. (1998)
Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein.
Oncogene. 16(22), 2843-2853.
Sato S, Roberts K, Gambino G, Cook A, Kouzarides T, Goding CR. (1997)
CBP/p300 as a co-factor for the Microphthalmia transcription factor.
Oncogene. 14(25), 3083-3092.
Lavender P, Vandel L, Bannister AJ, Kouzarides T. (1997)
The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.
Oncogene. 14(22), 2721-2728.
Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T. (1995)
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.
Oncogene. 11(12), 2509-2514.
Bannister AJ, Cook A, Kouzarides T. (1991)
In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.
Oncogene. 6(7), 1243-1250.
Kouzarides T, Packham G, Cook A, Farrell PJ. (1991)
The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper.
Oncogene. 6(2), 195-204.
Bryant LA, Mixon P, Davidson M, Bannister AJ, Kouzarides T, Sinclair JH. (2000)
The human cytomegalovirus 86-kilodalton major immediate-early protein interacts physically and functionally with histone acetyltransferase P/CAF.
J Virol. 74(16), 7230-7237.
Radkov SA, Touitou R, Brehm A, Rowe M, West M, Kouzarides T, Allday MJ. (1999)
Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription.
J Virol. 73(7), 5688-5697.
O’Connor MJ, Zimmermann H, Nielsen S, Bernard HU, Kouzarides T. (1999)
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.
J Virol. 73(5), 3574-3581.
Hagemeier C, Walker S, Caswell R, Kouzarides T, Sinclair J. (1992)
The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.
J Virol. 66(7), 4452-4456.
Erhardt S, Su IH, Schneider R, Barton S, Bannister AJ, Perez-Burgos L, Jenuwein T, Kouzarides T, Tarakhovsky A, Surani MA. (2003)
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
Development. 130(18), 4235-4248.
Bannister AJ, Kouzarides T. (2004)
Histone methylation: recognizing the methyl mark.
Methods Enzymol. 376, 269-288.
Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP. (2003)
The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains.
Trends Biochem Sci. 28(2), 69-74.
Schneider R, Bannister AJ, Kouzarides T. (2002)
Unsafe SETs: histone lysine methyltransferases and cancer.
Trends Biochem Sci. 27(8), 396-402. Review.
Brehm A, Kouzarides T. (1999)
Retinoblastoma protein meets chromatin.
Trends Biochem Sci. 24(4), 142-145. Review.
Burgers WA, Fuks F, Kouzarides T. (2002)
DNA methyltransferases get connected to chromatin.
Trends Genet. 18(6), 275-277.
Kouzarides T. (1995)
Functions of pRb and p53: what’s the connection?
Trends Cell Biol. 5(12), 448-450.
KouzaridesT. (1993)
Transcriptional regulation by the retinoblastoma protein.
Trends Cell Biol. 3(7), 211-213.
Kouzarides T. (2002)
Histone methylation in transcriptional control.
Curr Opin Genet Dev. 12(2), 198-209. Review. Erratum in: Curr Opin Genet Dev 12(3), 371.
Kouzarides T. (1999)
Histone acetylases and deacetylases in cell proliferation.
Curr Opin Genet Dev. 9(1), 40-48. Review.
Ozdag H, Batley SJ, Forsti A, Iyer NG, Daigo Y, Boutell J, Arends MJ, Ponder BA, Kouzarides T, Caldas C. (2002)
Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours.
Br J Cancer. 87(10), 1162-1165.
Brehm A, Miska E, Reid J, Bannister A, Kouzarides T. (1999)
The cell cycle-regulating transcription factors E2F-RB.
Br J Cancer. 80 Suppl 1, 38-41. Review.
Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T, Zernicka-Goetz M. (2006)
Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos.
Int J Dev Biol. 50(5), 4554-61.
Arney KL, Bao S, Bannister AJ, Kouzarides T, Surani MA. (2002)
Histone methylation defines epigenetic asymmetry in the mouse zygote.
Int J Dev Biol. 46(3), 317-320.
Turlais F, Hardcastle A, Rowlands M, Newbatt Y, Bannister A, Kouzarides T, Workman P, Aherne GW. (2001)
High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate).
Anal Biochem. 298(1), 62-68.
Avots A, Buttmann M, Chuvpilo S, Escher C, Smola U, Bannister AJ, Rapp UR, Kouzarides T, Serfling E. (1999)
CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.
Immunity. 10(5), 515-524.
Kouzarides T. (2003)
Wellcome Trust Award Lecture. Chromatin-modifying enzymes in transcription and cancer.
Biochem Soc Trans. 31(Pt 4), 741-743.
Kouzarides T. (1998)
Transcription factors and cell differentiation. 20th Annual Symposium, Burnham Institute, La Jolla, CA, USA, 22 May 1998.
Biochim Biophys Acta. 1378(3), R59-R61.
Huntley R, Healy S, Freeman D, Lavender P, de Jager S, Greenwood J, Makker J, Walker E, Jackman M, Xie Q, Bannister AJ, Kouzarides T, Gutierrez C, Doonan JH, Murray JA. (1998)
The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
Plant Mol Biol. 37(1), 155-169.
Samudyata, Amaral PP, Engström PG, Robson SC, Nielsen ML, Kouzarides T, Castelo-Branco G. (2019)
Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.
Exp Cell Res. 381(1):129-138.
Vallian S, Gaken JA, Trayner ID, Gingold EB, Kouzarides T, Chang KS, Farzaneh F. (1997)
Transcriptional repression by the promyelocytic leukemia protein, PML.
Exp Cell Res. 237(2), 371-382.
Kouzarides T. (1995)
Transcriptional control by the retinoblastoma protein.
Semin Cancer Biol. 6(2), 91-98. Review.
Martin K, Trouche D, Hagemeier C, Kouzarides T. (1995)
Regulation of transcription by E2F1/DP1.
J Cell Sci Suppl. 19, 91-94. Review.
Caswell R, Hagemeier C, Chiou CJ, Hayward G, Kouzarides T, Sinclair J. (1993)
The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation.
J Gen Virol. 74 ( Pt 12), 2691-2698
Stimson L, Rowlands MG, Newbatt YM, Smith NF, Raynaud FI, Rogers P, Bavetsias V, Gorsuch S, Jarman M, Bannister A, Kouzarides T, McDonald E, Workman P, Aherne GW. (2005)
Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.
Mol Cancer Ther. 4(10), 1521-1532.
Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED. (2012)
The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4.
J Mol Biol. 422(1), 3-17.
Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ. (2005)
Crystal structure of the ENT domain of human EMSY.
J Mol Biol. 350(5), 964-973.
Rodriguez C, Hughes-Davies L, Valles H, Orsetti B, Cuny M, Ursule L, Kouzarides T, Theillet C. (2004)
Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome.
Clin Cancer Res. 10(17), 5785-5791.
Ozdag H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, Bobrow L, Veerakumarasivam A, Burtt G, Subkhankulova T, Arends MJ, Collins VP, Bowtell D, Kouzarides T, Brenton JD, Caldas C. (2006)
Differential expression of selected histone modifier genes in human solid cancers.
BMC Genomics. 7, 90.
Lando D, Balmer J, Laue ED, Kouzarides T. (2012)
The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.
PLoS One. 7(1), e29765.
Opel M, Lando D, Bonilla C, Trewick SC, Boukaba A, Walfridsson J, Cauwood J, Werler PJ, Carr AM, Kouzarides T, Murzina NV, Allshire RC, Ekwall K, Laue ED. (2007)
Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1.
PLoS ONE. 2(4), e386.
Wiese M, Bannister AJ, Basu S, Boucher W, Wohlfahrt K, Christophorou MA, Nielsen ML, Klenerman D, Laue ED, Kouzarides T. (2019)
Citrullination of HP1γ chromodomain affects association with chromatin.
Epigenetics Chromatin.12(1):21.
Murata K, Kouzarides T, Bannister AJ, Gurdon JB. (2010)
Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes.
Epigenetics Chromatin. 3(1), 4.
Dawson MA, Kouzarides T, Huntly BJ. (2012)
Targeting epigenetic readers in cancer.
N Engl J Med. 367(7), 647-657.
Dawson MA, Bannister AJ, Saunders L, Wahab OA, Liu F, Nimer SD, Levine RL, Göttgens B, Kouzarides T, Green AR. (2011)
Nuclear JAK2.
Blood. 118(26), 6987-6988.
Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. (2012)
ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation.
Stem Cells. 30(12), 2672-2682.
Dawson MA, Gudgin EJ, Horton SJ, Giotopoulos G, Meduri E, Robson S, Cannizzaro E, Osaki H, Wiese M, Putwain S, Fong CY, Grove C, Craig J, Dittmann A, Lugo D, Jeffrey P, Drewes G, Lee K, Bullinger L, Prinjha RK, Kouzarides T, Vassiliou GS, Huntly BJ. (2013)
Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.
Leukemia. 28(2), 311-320.
Wyspianska BS, Bannister AJ, Barbieri I, Nangalia J, Godfrey A, Calero-Nieto FJ, Robson S, Rioja I, Li J, Wiese M, Cannizzaro E, Dawson MA, Huntly B, Prinjha RK, Green AR, Gottgens B, Kouzarides T. (2014)
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.
Leukemia. 28(1), 88-97.
Castelo-Branco G, Amaral PP, Engström PG, Robson SC, Marques SC, Bertone P, Kouzarides T. (2013)
The non-coding snRNA 7SK controls transcriptional termination, poising and bidirectionality in embryonic stem cells.
Genome Biol. 14(9), R98.
Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O’Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S (2015).
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.
Cancer Res 75(23):5106-5119
Theodoulou NH, Bamborough P, Bannister AJ, Becher I, Bit RA, Che KH, Chung CW, Dittmann A, Drewes G, Drewry DH Gordon L, Grandi P, Leveridge M, Lindon M, Michon AM, Molnar J, Robson SC, Tomkinson NC, Kouzarides T, Prinjha RK (2015)
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
J Med Chem. 2015 Apr 30. [Epub ahead of print]
Bamborough P, Chung C-W, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T, Michon A-M, Mitchell DJ, Prinjha RK, Rau C, Robson S, Sheppard RJ, Upton R, Watson RJ (2016).
A Chemical Probe for the ATAD2 Bromodomain.
Angew Chem Int Ed Engl 55(38):11382-11386
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